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Efficacy on Lambda Variant : SARS-CoV-2 Lambda variant Mutation Report

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  • Efficacy on Lambda Variant : SARS-CoV-2 Lambda variant Mutation Report

SARS-CoV-2 Lambda variant Mutation (lineage C.37):

The SARS-CoV-2 Lambda variant, also known as lineage C.37, is a variant of SARS-CoV-2, the virus that causes COVID-19. It was first detected in Peru in December 2020. On 14 June 2021, the World Health Organization (WHO) named it Lambda variant and designated it as a variant of interest. It has spread to at least 30 countries] around the world and may be more resistant to COVID-19 vaccines compared to other strains. It is also suggested that the Lambda variant is more infectious than the Alpha or Gamma variant.

Mutations:

The Lambda genome has the following amino acid mutations, all of which are in the virus’s spike protein code: G75V, T76I, Δ246-252, L452Q, F490S, D614G and T859N.

The E484Q mutation is present in the B.1.617.2 genome.

Classification:

The Lambda variant has mutations in the gene encoding the SARS-CoV-2 spike protein causing the substitutions Del246_252, F490S, G75V, L452Q, T76I, T859N and D614G.

Conclusion:

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new coronavirus associated with severe acute respiratory syndrome. We used a molecular docking protocol to anticipate possible sites for nine ligands from the Protein Data Bank’s twelve SARS-CoV-2 Lambda variant Mutation proteins. The current analysis reveals that 7 mutated SARS-CoV-2 Lambda variant Mutation protein interacted with nine ligands and showed the best interaction with all Del246_252, F490S, G75V, L452Q, T76I, T859N and D614G with binding energy greater than -5.00 (kcal/mol). Using Docking research, all nine compounds of Vedicinal 9 had the best interactions with the mutant protein. As shown by the single asterisk (*), the binding energies range from -5.01 to -6.99 kcal/mol, indicating a promising result and excellent binding energy. The range of -7.01 to -8.99, shown by a double asterisk (**), indicates a high binding energy and is extremely effective against the SARS-CoV-2 Lambda mutation.
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